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tecovirimat will increase the level or result of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Watch. Tecovirimat is usually a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse outcomes if coadministered with delicate substrates of those enzymes.posaconazole will increase the level or result of modafinil by influenci